Clinical Trials for Migraine in the U.S. - Currently Recruiting
Trial of Eptinezumab in Participants with Migraine and Insufficient Response to Anti-CGRP Medications
- Location: Various Headache Centers across the US. Click link above.
- Description: The purpose of this study is to learn whether eptinezumab improves migraine symptoms and quality of life of participants with migraine who did not perceive a sufficient improvement during previous treatment with therapies targeting calcitonin gene-related peptide (CGRP).
- Enrollment: 150
- Conditions: Migraine
- Age Group: Adult
Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults (E-BEOND)
- Location: Various Headache Centers across the US. Click link above.
- Description: The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing episodic migraine.
- Enrollment: 714
- Conditions: Migraine
- Age Group: Adult
Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults (C-BEOND)
- Location: Various Headache Centers across the US. Click link above.
- Description: The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic migraine.
- Enrollment: 720
- Conditions: Migraine
- Age Group: Adult
Study of Pregnancy Outcomes in Women Exposed to Migraine Medication
- Location: Research Triangle Institute d/b/a RTI Health Solutions, Durham, North Carolina
- Description: The purpose of the study is to evaluate the risk of adverse pregnancy outcomes in women exposed to migraine medications.
- Enrollment: 8082
- Conditions: Migraine
- Age Group: Child, Adult
Family Study of Affective and Anxiety Spectrum Disorders
- Location: National Institutes of Health Clinical Center, Bethesda, Maryland
- Description: This study will examine how depression, anxiety, and related disorders run in families, and how these disorders are related to other medical conditions like migraines.
- Enrollment: 3975
- Conditions: Mood Disorders, Sleep Disorders, Migraine
- Age Group: Child, Adult, Older Adult
Aimovig Pregnancy Exposure Registry
- Location: IQVIA Virtual Site, Durham, North Carolina
- Description: The primary objective of this study is to estimate the risk of major congenital malformations in infants following exposure to Aimovig during pregnancy.
- Enrollment: 2842
- Conditions: Migraine
- Age Group: Adult, Older Adult
Randomized Study in Children and Adolescents With Pediatric Migraine
- Location: Accel Research Sites-Neurology and Neurodiagnostics of Alabama, Birmingham, Alabama
- Description: The purpose of this study is to test the safety and effectiveness of a new treatment for pediatric migraine.
- Enrollment: 2100
- Conditions: Pediatric Migraine
- Age Group: Child
Observational Study to Assess Adverse Events With Migraine Treatments
- Location: Iqvia, Durham, North Carolina
- Description: Migraine is a common neurological disorder typically treated with a range of medications. This observational study aims to assess the adverse events associated with these treatments.
- Enrollment: 1884
- Conditions: Migraine
- Age Group: Adult, Older Adult
A Study of Lasmiditan (LY573144) Treatment in Migraine
- Location: Central Research Associates, Birmingham, Alabama
- Description: The reason for this study is to see if lasmiditan is effective in treating migraines.
- Enrollment: 1633
- Conditions: Migraine
- Age Group: Child
NIMH Rhythms and Blues Study: A Prospective Naturalistic Study
- Location: National Institutes of Health Clinical Center, Bethesda, Maryland
- Description: This study aims to explore the relationship between mood disorders, such as bipolar disorder and major depression, and migraines.
- Enrollment: 1260
- Conditions: Bipolar Disorder, Major Depression, Migraine
- Age Group: Child, Adult, Older Adult
Study to Assess Adverse Events and Disease Activity in Migraine Patients
- Location: Rehabilitation & Neurological Services, Tucson, Arizona
- Description: Migraine is a common neurological disorder typically treated with a range of medications. This study aims to assess adverse events and disease activity in migraine patients.
- Enrollment: 1059
- Conditions: Migraine
- Age Group: Child
A 12-Month Study of Lasmiditan (LY573144) Treatment in Migraine
- Location: Central Research Associates, Birmingham, Alabama
- Description: The reason for this 12-month, open-label study is to see if lasmiditan is effective in treating migraines.
- Enrollment: 1000
- Conditions: Migraine
- Age Group: Child
Assessing Symptom and Mood Dynamics in Pain Using Smartphone Applications
- Location: Brown University, Providence, Rhode Island
- Description: This study relies on the use of a smartphone application to assess symptom and mood dynamics in individuals with chronic and acute pain conditions, including migraines.
- Enrollment: 800
- Conditions: Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Migraine
- Age Group: Adult, Older Adult
FAQs About Clinical Trials for Migraine
What Is A Clinical Trial?
A clinical trial is a scientific study conducted to ascertain the effectiveness and safety of new medical approaches in humans. Clinical trials for migraines specifically aim to investigate new treatments, therapies, or interventions that can alleviate the symptoms of migraines. These trials may test novel medications, explore the effectiveness of certain lifestyle changes, or even investigate the use of medical devices.
How Do Clinical Trials for Migraines Work?
Considering that more than 42 million U.S. adults live with migraine, clinical trials are a crucial part of medical research, involving the systematic exploration and testing of new treatments or interventions. The aim is to assess their effectiveness and safety in relieving the often debilitating symptoms of migraines.
Through these trials, we can find solutions like innovating new drugs, determining the success of alternative therapies, or studying the influence of specific lifestyle changes. Participants in these trials often represent a spectrum of ages, medical histories, and migraine characteristics. This diverse group contributes to a rich data pool, which is key for understanding how the treatment interacts differently with various individuals.
Who Can Participate in a Migraine Clinical Trial?
Who can participate in a migraine clinical trial varies depending on the specific study. Generally, factors such as age, medical history, and specific migraine characteristics are considered. For age, some trials might be looking for adults, while others may be interested in children living with migraine or older adults.
Medical history could include factors like how long you've had migraines, their severity, frequency, and whether or not other treatments have been tried or are currently being used. Specific migraine characteristics might entail the type of migraines experienced (for example, migraines with aura, chronic migraines, etc.).
What Are The Phases Of Clinical Trials?
Clinical trials typically progress through four phases: Phase I (safety testing), Phase II (effectiveness and side effects), Phase III (comparison with current treatments), and Phase IV (post-marketing surveillance).